A network of syringe-injectable bioelectronics for closed-loop therapeutic rescue

RES-Q, a syringe-implantable naloxone autoinjector network, delivers 0.4 mg naloxone and autonomously rescues fentanyl overdoses in rats in under 6 minutes.

• Why it matters: Rapid-onset opioid overdoses leave incapacitated victims unable to self-administer naloxone, and existing closed-loop devices are too bulky for acceptance.
• What they did: The Rapid Emergency Subcutaneous platform uses wearable sensors linked to syringe-implantable autoinjectors via tissue conductivity, with 25 nA standby current and dose-titration; it was tested in rats and swine.
• The result: In rats, RES-Q detects fentanyl overdoses via photoplethysmography and performs autonomous, dose-titratable rescue in < 6 minutes, supporting practical closed-loop emergency therapy.

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