A spatially continuous cell-type atlas reveals multiscale organization of the human cortex

RIDGE reconstructs spatially continuous maps of 24 major human cortical cell types, capturing cortex-wide organization and the canonical Pr-Al axis while enabling region-specific inference.

• Why it matters: Imaging shows fine spatial heterogeneity in cortex, but linking it to cellular architecture needs references that are continuous across the whole cortex and still support regional specialization.
• What they did: The RIDGE deconvolution framework anchors multiple regional references to continuous cortex-wide transcriptomic maps, then estimates cell-type distributions across the human cortex.
• The result: The resulting 24-cell-type maps are robust across pipelines and independent reference datasets, recover known cell-type–cortical feature links, and resolve system-specific profiles in default mode, motor, and visual areas.

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