The abstract is read at the publisher; the summary is JClub's.
MNT directly binds CCDC6 through the CCDC6 coiled-coil domain and the MNT bHLH-LZ region, with shared residues also required for MNT–MAX dimerization.
- Why it matters: The MYC-MAX-MXD network’s functions are not fully defined, and CCDC6’s role in the DNA damage response suggests potential cross-talk with transcriptional control.
- What they did: Using co-immunoprecipitation, interaction mapping, and structural modelling, the study pinpointed binding determinants and performed transcriptomic profiling to assess overlapping MNT and CCDC6 programs.
- The result: Loss of either MNT or CCDC6 promoted cell migration, while MNT and CCDC6 cooperated to regulate {gamma}H2AX signalling, cisplatin responses, and CCDC6 localization during the DDR.
The findingWhy it mattersWhat they didThe result
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