The abstract is read at the publisher; the summary is JClub's.
In 666 older adults from the FROM cohort, GrimAge acceleration is strongly linked to several chemical exposures, especially 2-hydroxyfluorene (2-HF: beta = 0.491 years per doubling, P = 1.22 x 10-14).
- Why it matters: The study addresses uncertainty about whether environmental chemicals relate to epigenetic aging and to metabolic or age-related clinical traits through measurable biological pathways.
- What they did: It tested 13 exposures (heavy metals, PAHs, VOCs) against epigenetic aging biomarkers, using quantile g-computation and Bayesian kernel machine regression, plus Mendelian randomization and mediation for GGT.
- The result: Combined exposures increased GrimAge acceleration (psi = 0.497, 95% CI: 0.013–0.981, P = 0.044), WBC and GGT rose with GrimAge acceleration, and mediation supported indirect effects via GrimAge acceleration for 2-HF, 2-NAP, bCd, and MHA.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.