The abstract is read at the publisher; the summary is JClub's.
Higher gut abundances of Scardovia and Limosilactobacillus are linked to increased incident major adverse cardiovascular events in the FINRISK 2002 cohort, with HRs of 1.17 and 1.16.
- Why it matters: Evidence linking the gut microbiome to cardiovascular outcomes is still incomplete, and replication across independent European cohorts is needed to identify reliable microbial risk markers.
- What they did: Gut microbiome composition was measured by shallow shotgun sequencing in FINRISK 2002 and tested with time-to-event models for incident MACE, then key taxa were replicated in HUNT, HELIUS, SIMPLER, and SCAPIS with meta-analysis (N=30,228; 1,938 incident MACE).
- The result: Meta-analysis confirmed robust associations for several taxa, including Scardovia (HR=1.17, p=0.0001) and Limosilactobacillus (HR=1.16, p=1E-06), which also related to cardiovascular and all-cause mortality.
The findingWhy it mattersWhat they didThe result
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