The abstract is read at the publisher; the summary is JClub's.
Loss of a distinct two-peak daily activity pattern (FPC2) is linked to higher all-cause mortality in NHANES adults, with hazard ratios around 1.17–1.18 per SD.
- Why it matters: Standard 24-hour cosinor summaries capture level, strength, and timing, but it is unclear whether the remaining within-day shape adds prognostic information for mortality.
- What they did: Adults with 7 valid accelerometry days were analyzed in two NHANES cohorts (hip 2003–2006, n=2,615; wrist 2011–2014, n=3,208), fitting a 24-hour cosinor per person and decomposing residual curves with (multilevel) FPCA; Cox models adjusted for covariates and cosinor parameters.
- The result: FPC2 explained 44% (hip) and 51% (wrist) of residual variance and replicated for all-cause mortality (hip HR 1.17, 95% CI 1.06–1.29, q=0.008; wrist HR 1.18, 1.03–1.35, p=0.017), concentrating on cardiovascular deaths with survey weights (hip p=0.007; wrist p=0.005) and persisting after further lifestyle/activity adjustment.
The findingWhy it mattersWhat they didThe result
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