The abstract is read at the publisher; the summary is JClub's.
Hierarchical/p-factor polygenic liability is robustly associated with 221 medical and laboratory conditions across 108,182 European-like and 13,229 African-like ancestry participants, spanning 15 disease categories (OR=0.75–1.94).
- Why it matters: Psychiatric diagnoses are poorly grounded biologically, so mapping shared genetic liability across transdiagnostic dimensions to broad medical and lab phenotypes can refine biologically informed subtypes.
- What they did: Using polygenic scores for five first-order psychopathology factors and one second-order factor, the study ran phenome-wide and laboratory-wide association scans across 1,520 medical phenotypes and 123 laboratory metrics, meta-analyzed across biobank sites.
- The result: Neurodevelopmental, internalizing, and substance use liabilities show links to circulatory, digestive, and respiratory diseases, while metabolic conditions are negatively associated with thought and compulsive liabilities and positively with the other three factors; lipid/glucose and immune markers (C-reactive protein, Complement C4) support these patterns.
The findingWhy it mattersWhat they didThe result
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