Beat-to-beat blood pressure variability and Alzheimers disease pathophysiology

Elevated beat-to-beat systolic blood pressure variability in independently living older adults (N=132) is linked to higher plasma p-Tau217 (β=0.32, p=0.008).

• Why it matters: Prior work emphasized visit-to-visit variability, which can reflect medication adherence and other external influences, leaving beat-to-beat variability’s relevance to Alzheimer’s pathology unclear.
• What they did: Older adults underwent continuous blood pressure monitoring and blood draws; linear regression tested associations between beat-to-beat systolic BPV and plasma AD biomarkers, adjusting for age, sex, systolic blood pressure, and APOE4 carrier status.
• The result: Beat-to-beat BPV also correlated with plasma p-Tau181 (β=0.22, p=0.05) and GFAP (β=0.41, p=0.00001), but showed no association with plasma amyloid-{beta}42/40 ratio or plasma NfL.

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