Preferential recruitment of PML isoform II by incoming HPV16 genome transport vesicles facilitates early stage of infection

PML isoform II (PMLII) is selectively attracted to incoming HPV16 genomes still inside nuclear transport vesicles, unlike other PML isoforms, in HeLa cells.

• Why it matters: The mechanism linking PML nuclear bodies to early HPV transcription and replication is unclear, despite known virion association with PML NBs.
• What they did: In HeLa cells, PML isoform and HPV16 L2 over-expression experiments showed PMLII recruitment depends on binding to vesicle lipids rather than L2, with transient PML NB–genome association.
• The result: PMLII-L1 complexes colocalize with nuclear Phospholipase C beta4 and gamma1, supporting a model that PMLII helps establish early HPV16 infection by organizing host lipid regulatory factors at incoming vesicles.

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