The abstract is read at the publisher; the summary is JClub's.
Maternal e-cigarette aerosol exposure in pregnant rats increases tMCAO-induced infarct size in male offspring at postnatal day 10, linked to miR-30c-5p–Neurod1 dysregulation.
- Why it matters: Neonatal ischemic stroke causes major mortality and long-term disability, yet how prenatal e-cigarette exposure heightens vulnerability is unclear.
- What they did: Pregnant rats were exposed to e-cigarette aerosols from embryonic day 4 to 20, then male pups underwent tMCAO and baseline miRNA/molecular profiling; miR-30c-5p mimic, inhibition, and Neurod1 knockdown were tested in vivo.
- The result: miR-30c-5p was increased with decreased Neurod1 mRNA/protein, and miR-30c-5p–Neurod1 binding was supported; mimic worsened injury, while miR-30c-5p inhibition restored Neurod1 and reduced infarct size.
The findingWhy it mattersWhat they didThe result
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