The abstract is read at the publisher; the summary is JClub's.
In post-mortem middle frontal gyrus tissue from 11 CTE-NC cases versus 11 age-matched controls, perivascular tau lesions were not linked to large-scale PVS enlargement or microvascular degeneration.
- Why it matters: The study addresses whether CTE-NC’s perivascular phosphorylated tau pathology reflects a classical small-vessel degenerative phenotype, or instead occurs without major structural vascular changes.
- What they did: Using immunohistochemistry, the authors quantified PVS width, PVS area, PVS-to-lumen area ratio, string vessel burden, pericyte density, and aquaporin-4 (AQP4) endfoot enrichment, comparing CTE-NC and controls across sulcal depth and gyral crest.
- The result: No significant group differences were found (e.g., total PVS width P=0.543 grey matter; P=0.468 white matter; microvascular metrics P≥0.128), implying the tau lesions are not associated with the measured structural small-vessel phenotype.
The findingWhy it mattersWhat they didThe result
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