The abstract is read at the publisher; the summary is JClub's.
In the 2000HIV cohort of 1895 people with HIV on antiretroviral therapy, total HIV DNA in circulating CD4+ T cells is linked to older biological aging scores and adverse virologic outcomes.
- Why it matters: Treated people with HIV still face premature aging and non-AIDS comorbidities, but it is unclear whether reservoir size and activity relate to these health outcomes during suppressive therapy.
- What they did: The study quantified total and intact proviral HIV DNA and cell-associated HIV RNA, then tested associations with historic and prospective virologic/immunologic markers, comorbidity outcomes, and biological aging scores.
- The result: Total HIV DNA correlated with prevalent cardiovascular disease, subclinical atherosclerosis, liver fibrosis, and incident malignancies independent of circulating inflammatory markers and lowest CD4 nadir, while HIV RNA linked to prevalent cardiovascular disease and liver fibrosis.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.