The abstract is read at the publisher; the summary is JClub's.
Contact between GARP/TGF-β1–presenting cells and integrin Vβ6 or Vβ8–expressing cells triggers rapid trogocytosis that transfers latent complex components.
- Why it matters: It was unclear how integrin engagement converts surface-tethered latent TGF-β1 into signaling-competent growth factor and how this shapes which neighboring cells respond.
- What they did: The authors used independent labeling of prodomain, growth factor, and GARP, tested an integrin-binding–defective TGF-β1 mutant (RGE), and applied a pathway reporter plus cleavage-blocking and GF-neutralizing antibodies.
- The result: By transferring all three components, trogocytosis enables integrin-expressing cells to activate latent TGF-β1 and signal to bystander cells after donor removal, while antibody and cleavage blockade show bystander signaling depends on transferred GF activation.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.