The abstract is read at the publisher; the summary is JClub's.
Processed CRNDE UCE-retaining transcripts are detected across 380 of 382 assessable primary colorectal tumors, and region-specific nucleolar enrichment is seen for selected lncRNAs.
- Why it matters: Gene-level lncRNA profiling can miss processed RNA architectures and subcellular localization, limiting how CRC lncRNAs are interpreted relative to snoRNP-linked nucleolar biology.
- What they did: The authors integrated CRC tumor expression and clinical evidence with published HEK293 CLIP for C/D snoRNP proteins and long-read sequencing to retain CLIP-supported regions, then used region-directed RT-qPCR after pre-ribosome sequential extraction in Caco-2 and a second CRC cell model.
- The result: They identified 1,714 disease-supported lncRNAs with CLIP overlap and retained 188 CLIP-supported regions within processed transcripts from 65 loci; JPX, DLEU2, and LINC00630 showed preferential core nucleolar enrichment.
The findingWhy it mattersWhat they didThe result
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