The abstract is read at the publisher; the summary is JClub's.
In Arabidopsis thaliana, the GSNOR-deficient gsnor1-3 mutant retains far more directionally persistent CG DMRs across G3 and G5 after future-climate exposures than wild type, reaching 44.1–45.7%.
- Why it matters: Environmental stress can reshape plant DNA methylation, but how nitric oxide homeostasis affects methylome recovery and multigenerational persistence is unclear.
- What they did: Whole-genome bisulfite sequencing compared wild type and gsnor1-3 across G1–G3 under drought, elevated CO2, ozone, heat, or combinations, then assessed G3 and G5 after two control generations, integrating matched RNA-seq and independent datasets.
- The result: gsnor1-3 showed a strong hypermethylation bias and far more persistent CHG and CHH DMRs; independent data supported directional agreement for 211 of 292 published GSNOR-associated DMRs, implying GSNOR-dependent nitric oxide homeostasis stabilizes and resets methylomes.
The findingWhy it mattersWhat they didThe result
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