The abstract is read at the publisher; the summary is JClub's.
Dextrorphan (DXO) and its derivatives trigger rapid mTOR-linked signaling and universal ROR1 activation in pancreatic islets, and ROR1/2 supports islet viability.
- Why it matters: NMDAR inhibition is linked to improved insulin secretion and protection from islet death, but the downstream signaling logic remains unclear.
- What they did: Using phosphoproteomics and tyrosine kinase profiling, the study mapped DXO-driven signaling clusters in pancreatic islets and tested whether blocking mTOR or ERK alters DXO protection.
- The result: mTOR inhibition, but not ERK inhibition, negates DXO’s protective effects, and Ror1/ROR1 plus Ror2/ROR2 knockdown reduces viability in both mouse and human islets.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.