The abstract is read at the publisher; the summary is JClub's.
ADHD and ASD polygenic scores show consistent direct genetic effects on corresponding traits across ages 4–26 in the Twins Early Development Study, while within-trait indirect evidence is limited.
- Why it matters: Polygenic links to neurodevelopmental traits may include direct and indirect genetic effects, but prior evidence is mixed and seldom tracks development or compares reporters and methods.
- What they did: Using eight PGS, the study triangulated twin-comparison and trio-based analyses with up to 7,259 offspring and repeated parent, teacher, and self-reports of ADHD and ASD traits from ages 4 to 26.
- The result: Both approaches supported direct effects of ADHD and ASD PGS on matching traits, with limited within-trait indirect effects; cross-trait indirect effects appeared for several PGS, especially in parent reports, and some were unexpectedly negative.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.