The abstract is read at the publisher; the summary is JClub's.
In a randomized double-blind trial (N = 39) after an Ayahuasca-inspired DMT + harmine meditation retreat, central executive network control energy increased post-retreat in the verum group.
- Why it matters: Psychedelics may flatten the brain’s control energy landscape acutely, but whether such reorganization persists during the subacute afterglow window is unclear for therapy-relevant timing and durability.
- What they did: Using rs-fMRI collected before and after a three-day retreat, the study estimated control energy on an HCP structural connectome with long- and short-timescale modeling approaches, plus a rare-state analysis (top decile information content).
- The result: Long-timescale results showed a post-retreat CEN control-energy increase in the verum group that survived FDR-BH correction, while DMN increases did not; short-timescale modeling found a FDR-BH VN control-energy decrease in the verum group.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.