The abstract is read at the publisher; the summary is JClub's.
A 24-protein proteomic aging signature in women’s vastus lateralis separates all younger (24–30) from all elderly (70–84) and tracks physical function decline.
- Why it matters: Aging-related loss of strength and mobility in women lacks clear molecular readouts tied to functional performance, limiting intervention targeting.
- What they did: Using deep DIA proteomics on vastus lateralis biopsies from 10 younger and 10 older healthy women, they quantified 2,391 protein groups and built a signature linked to grip strength and gait speed.
- The result: The signature score correlated strongly with combined function (r = -0.79), with 23/24 proteins associated (FDR < 0.05), and HMGB1 (r = -0.86) and HMGB2 emerging as lead markers.
The findingWhy it mattersWhat they didThe result
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