Placental Klotho responses to supervised prenatal exercise: findings from the PLACENTRAINING study

Supervised concurrent prenatal exercise is linked to higher placental Klotho concentrations at birth, with an adjusted mean difference of ~101 pg/mL (p = 0.001) in 76 women.

• Why it matters: Regular exercise improves pregnancy outcomes, but the placental molecular adaptations—especially involving Klotho—are not well characterized, limiting mechanistic understanding.
• What they did: In the PLACENTRAINING study, pregnant women were assigned to supervised aerobic plus resistance training three times per week from early-mid pregnancy until birth or usual care; placental Klotho was measured at birth by ELISA.
• The result: Placental Klotho was higher in the exercise group, with no significant exercise-by-sex interaction, and multiple placental angiogenic/inflammatory biomarkers were independently associated with Klotho.

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