BSG.S regulates ionocyte radial intercalation and function in the developing Xenopus mucociliary epithelium.

BSG.S is expressed in ionocytes of the developing Xenopus laevis mucociliary epithelium, and its depletion impairs ionocyte radial intercalation and epithelial organization.

• Why it matters: Mucociliary epithelia depend on correctly specified and spatially organized ionocytes and other cell types, but how ionocytes integrate during development is not well understood.
• What they did: The authors examined BSG.S expression in ionocytes and then depleted BSG.S to test effects on ionocyte radial intercalation, intracellular pH, and epithelial organization in developing Xenopus laevis MCE.
• The result: BSG.S loss disrupts ionocyte integration and pH homeostasis and shifts cell-type composition by decreasing basal cells and increasing multiciliated cells, suggesting a role in epithelial organization during development.

AI summary of the abstract · may contain errors · not medical advice · read the paper.