Single-base mapping of m6A in lncRNAs reveals a distinct landscape linked to transposable elements and RNA processing

Single-base mapping shows m6A sites are broadly distributed across long noncoding RNAs, revealing a distinct landscape compared with mRNAs and linking it to specific sequence and processing features.

• Why it matters: The lncRNA m6A landscape and its functional connections to RNA processing are poorly defined, despite known roles of m6A in mRNA metabolism and some characterized lncRNAs.
• What they did: The authors profiled m6A in lncRNAs at single-base resolution, then analyzed deposition-associated features and compared patterns with mRNAs, focusing on motif availability, local RNA structure, exon-junction proximity, and polyadenylation.
• The result: Differences between lncRNAs and mRNAs are linked to transposable element-derived sequence affecting motifs and RNA structure, splicing-related constraints near exon junctions, and m6A’s potential relevance to lncRNA polyadenylation.

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