Shared and Specific miRNA-mRNA in Human and Murine Acute Kidney Injury

Etiology-specific miRNA–mRNA programs in kidney distinguish three murine acute kidney injury models, and human whole-blood RNAseq aligns along a shared gene axis linked to model severity.

• Why it matters: AKI is treated as one condition despite biological heterogeneity, and it is unclear how molecular programs differ by cause and map onto human disease.
• What they did: Parallel sequencing of totalRNA mRNA and miRNA (kidney and whole blood) was performed in ischemia-reperfusion injury, cecal-ligation and puncture, and endotoxemia, then compared with human whole-blood RNAseq.
• The result: Murine kidney signatures separated by etiology (e.g., miR-125b-1-3p, miR-692, miR-155-5p), while human samples varied along a shared gene axis correlated with all three models, supporting circulating biomarker development.

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