Delayed-centrifugation blood collection tube for remote blood biomarker assessment

P100 tubes best preserved plasma p-tau217 after 5-day ambient storage, showing rho=0.98 rank-order correlation and only a +12.1% median change versus fresh EDTA.

• Why it matters: Preanalytical handling can undermine reliability of AD biomarkers, and it is unclear whether alternative stabilization tubes maintain p-tau217 and Aβ42 measurements for remote collection.
• What they did: In 40 participants, paired plasma from fresh EDTA, P100, and HEMAcollect tubes were tested on Lumipulse after 5-day ambient storage, evaluating concentration change, Spearman rho, percentage difference, and diagnostic classification using p-tau217/Aβ42 ratio and p-tau217 alone.
• The result: P100 achieved 97.5% classification agreement with fresh EDTA using p-tau217 alone, while HEMAcollect caused −57.5% p-tau217 loss; Aβ42 fell in both tubes (−72.8% with P100; −95.5% with HEMAcollect), so neither preserved the p-tau217/Aβ42 ratio.

AI summary of the abstract · may contain errors · not medical advice · read the paper.