State-independent functional connectomic architecture captures transdiagnostic network alterations and clinical variation

Two reproducible state-independent connectivity alterations emerge across seven fMRI states in 377 YaleNeuroConnect participants, including a cerebello-cortical pattern linked to clinical variation.

• Why it matters: Psychiatric diagnoses overlap yet differ clinically, and it remains unclear whether shared abnormalities and individual differences reflect stable, state-independent brain architecture rather than task-specific connectivity.
• What they did: Principal component analysis derived a state-independent connectivity representation from each participant’s functional connectivity across one resting-state and six task-based conditions, followed by network-based statistics for case-control differences and validation in a separate UCLA cohort.
• The result: The cerebello-cortical connectivity pattern showed consistent case-control differences across states and generalized to UCLA, and greater expression associated with lower positive affect, greater psychopathology, and more everyday executive difficulties in the Yale psychiatric group.

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