Remodeling of α1-Acid Glycoprotein Glycoforms During Long-Term Calorie Restriction

Long-term calorie restriction in non-obese adults remodels α1-acid glycoprotein (AGP1) N-glycosylation, increasing branching at sites IV and V and raising fucosylation after 24 months.

• Why it matters: AGP1 is an acute-phase, immunometabolic protein whose glycosylation is poorly understood during metabolic interventions, despite links between AGP glycoforms and leptin receptor activity.
• What they did: In a pilot study of n = 26 adults with 2 years of calorie restriction (25% CR; ~12% CR overall; ~8.2 kg weight loss), AGP1 glycosylation at 5 sites was profiled from 0 to 24 months.
• The result: Calorie restriction increased branching at sites IV and V (p<0.05, FDR corrected) and increased fucosylation (p<0.05, FDR corrected), and exploratory analyses linked highly sialylated site IV and low-branched site I glycans to leptin (p<0.05).

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