Concordance with the MIND diet is associated with lower subsequent epigenetic aging

In 1,740 Health and Retirement Study participants, each 1-s.d. higher MIND diet score is linked to lower subsequent epigenetic aging, including -0.4 years PhenoAge acceleration.

• Why it matters: Evidence is limited on whether the MIND diet predicts biological aging over time, and whether epigenetic aging can serve as an intermediate link between diet and aging.
• What they did: Dietary data from 2013 were linked to 2016 DNA methylation measures, testing associations between MIND score and PhenoAge acceleration, GrimAge acceleration, and methylation Pace of Aging with FDR q≤0.026.
• The result: Associations persisted after body-mass-index adjustment and selection weighting, and concordance across models supports molecular aging as an intermediate phenotype for diet-aging research.

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