Proteomics reveals conserved features of histone biology in dinoflagellates

Proteomics of purified nuclei from Oxyrrhis marina and Amphidinium carterae confirmed all four core histone classes plus DVNP, and detected histone post-translational modifications.

• Why it matters: Dinoflagellates diverge from the nucleosome-centered view, yet their chromatin components and histone biology remain unclear, especially how DVNP and histone-like proteins are regulated.
• What they did: The team performed proteomics on purified nuclei from the two dinoflagellates, then used comparative genomics to assess histone-handling and modification machinery and replication-dependent nucleosome deposition factors.
• The result: Genomic and proteomic evidence suggests nucleosomes function mainly in transcription-associated chromatin, with canonical nucleosomes localized to insulated chromatin territories (INTs).

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