The Canadian Pediatric Imaging Platform (C-PIP) Reference Sample: Neuroimaging Protocol and Cross-site Validation for Harmonized Multimodal Pediatric Imaging

C-PIP created a harmonized multisite multimodal MRI protocol across Alberta Children’s Hospital, Sainte-Justine, and the Hospital for Sick Children, validated for within- and cross-site stability using travelling participants.

• Why it matters: Pediatric brain development studies are often limited by small samples, narrow age coverage, heterogeneous MRI acquisition, and limited longitudinal data, leaving a Canada-specific resource gap.
• What they did: The platform implemented a centralized data-sharing framework and developed core MRI sequences for longitudinal typical and atypical development from infancy through adolescence, then assessed stability with a travelling-participant design.
• The result: The validated protocol provides a harmonized framework for large-scale Canadian studies of pediatric brain development and disorders, enabling consistent multimodal longitudinal research across sites.

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