The abstract is read at the publisher; the summary is JClub's.
IL18 is relatively enriched in human cardiac pericytes, while CASP1, CASP4, and GSDMD are enriched in endothelium, confirmed in 22 adult non-failing donors.
- Why it matters: IL-18 maturation and release depend on inflammatory caspases and gasdermin D, but how these steps are partitioned across cardiac microvascular cell types is unclear.
- What they did: Using donor-paired single-nucleus RNA-seq comparisons across two discovery cohorts (42 and 38 donors), the authors predicted four expression directions and confirmed them against prespecified criteria in 22 adult non-failing donors.
- The result: The same pericyte-versus-endothelium expression pattern held in cardiomyopathy (IL18 in 51/52; CASP1, CASP4, GSDMD in 52/52) and was preserved across five ischaemic-heart resources, supporting a cell-to-cell division-of-labour model.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.