The abstract is read at the publisher; the summary is JClub's.
RNAquarium analyzes all public zebrafish Danio rerio RNA-seq in the SRA and links a close relative of human influenza B virus to distinct host transcriptional states.
- Why it matters: Existing zebrafish RNA-seq analyses are siloed and ignore the non-zebrafish reads, limiting discovery of microbial or viral drivers of transcriptomic states.
- What they did: The framework jointly performs transcriptomic and metatranscriptomic profiling across archive-scale zebrafish RNA-seq, then couples detected taxa to host gene-expression structure.
- The result: It reveals diverse microbial and viral associations, identifies previously undescribed zebrafish viruses, and enables foundation-model training and prediction of infection-linked transcriptomic signatures.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.