Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovary

Single-nucleus profiling of the postmenopausal human ovary resolved 37 cell states across 439,011 nuclei from 64 samples, revealing age-linked stromal stress expansion and immune/vascular depletion.

• Why it matters: The postmenopausal ovary is often treated as quiescent, but its aging cell biology is not well mapped, limiting understanding of how aging and life history shape later-life tissue states.
• What they did: The study built a single-nucleus atlas from 28 donors and created an interactive explorer; age-associated shifts were cross-supported using an external GTEx ovary bulk RNA-seq cohort.
• The result: Parity (1–3 versus 0 live births) is associated with transcriptional and compositional patterns that broadly oppose age-associated remodeling, enabling later-life molecular signatures tied to obstetric history.

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