The abstract is read at the publisher; the summary is JClub's.
Spreading depolarization (SD) in mouse dorsal cortex, not seizure activity, accounts for increased Fos immediate early gene expression after electroconvulsive stimulation (ECS).
- Why it matters: ECT is effective but its mechanism is unclear, and seizure-centric explanations are challenged by evidence that ECS triggers SD, which can drive large molecular responses.
- What they did: In mouse dorsal cortex, neuronal responses to ECS were recorded and compared with patient-like activity; Fos expression was quantified and linked to SD versus seizure activity, with EEG features also assessed.
- The result: SD is associated with increased Fos expression and with EEG features that predict positive ECT treatment outcome in patients, suggesting SD may be a relevant biomarker for predicting and optimizing outcomes.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.