Spatiospectral signatures of stomach-brain synchrony

At rest, human gastric rhythm (~0.05 Hz) is linked to widespread broadband phase-amplitude coupling across delta, theta, alpha, and beta MEG activity, with a stable preferred gastric phase.

• Why it matters: The temporal dynamics of how stomach intrinsic rhythms modulate human neural activity are poorly understood, limiting knowledge of brain-body coordination beyond general “brain-body” recognition.
• What they did: Using high-resolution MEG and high-density electrogastrography (EGG), circular-linear correlation mapped gastric-brain coupling, and nonnegative matrix factorization extracted spatiospectral fingerprints overlapping fMRI gastric resting-state networks.
• The result: Multivariate Granger causality showed directed, frequency-specific gastric influence on communication between network components, and a consistent preferred gastric phase during the transition between stomach waves was stable across regions, frequencies, connections, and time.

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