The abstract is read at the publisher; the summary is JClub's.
Common genetic variants linked to tinnitus in 961,085 European-ancestry adults concentrate in limbic and cortical neuronal cell populations, not ascending auditory relay clusters, with amygdala excitatory cells showing z = 4.82.
- Why it matters: Tinnitus is heterogeneous and its genetic basis is unclear, including whether genetic signals overlap across different definitions and which brain cell types carry the heritable component.
- What they did: A GWAS meta-analysis of 19 European and US cohorts (75,584 cases; 885,501 controls) used LD score regression for SNP heritability and genetic correlations, then tested heritability enrichment across 31 superclusters and 461 cell clusters.
- The result: Five genome-wide significant loci (p < 5 x 10-8) were found, and cell-type enrichment highlighted midbrain inhibitory neurons, amygdala excitatory neurons, and medial ganglionic eminence interneurons, with MVP replication for amygdala excitatory and MGE interneurons under diagnostic-code definitions.
The findingWhy it mattersWhat they didThe result
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