The P-body component Edc3 is required for yeast proliferation in the phyllosphere

Edc3 is required for Candida boidinii proliferation on Arabidopsis thaliana leaves, where methanol use and environmental adaptation occur, with edc3{Delta} showing impaired growth.

• Why it matters: The role of P-bodies in natural plant-associated environments is unclear, limiting understanding of how post-transcriptional regulation supports yeast fitness outside laboratory conditions.
• What they did: The study deleted EDC3 and tested growth of methanol-utilizing Candida boidinii on Arabidopsis thaliana leaves, then used in vitro assays and microscopy to assess methanol-induced mRNAs, mimRNA granules, and P-body–granule interactions under oxidative stress.
• The result: In edc3{Delta}, mimRNA granule formation and mimRNA abundance were reduced; oxidative stress increased P-body–granule colocalization and suppressed methanol growth, while time-lapse imaging showed transient, dynamic colocalization.

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