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In Vivo Network-Level Cerebrovascular Mapping Reveals the Impact of Flow Topology on Capillary Stalls After Stroke
bioRxiv · · Preprint · Open access
Glandorf, Droux + 10 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In mouse cortex after stroke, divergent-to-convergent capillary subtypes show the highest capillary stall risk, with stalls and flow changes occurring within the same vascular networks.
- Why it matters: It remains unclear how large-scale flow connectivity and topology shape microvascular resilience or failure after stroke, limiting targeted interpretation of capillary dysfunction.
- What they did: OMNIMap combines extended-focus optical coherence microscopy, learning-based segmentation, and vessel-graph optimization to link capillary flow and stalls to network context, imaging over 60,000 capillaries.
- The result: Capillary stalls may persist until at least 7 days post-stroke, and local flow topology is linked to capillary vulnerability even when vessel structure, velocity, and network position do not fully explain it.
The findingWhy it mattersWhat they didThe result
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- Open access
- 4 cites