Research area · week to 3 Oct 2026

Calcium signaling and nucleotide metabolism

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Latest in Calcium signaling and nucleotide metabolism

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Lysosomes enlist endoplasmic reticulum microdomains for repair.
Nature Cell Biology · 23 Sept 2026 · Journal Article
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Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum.
Proceedings of the National Academy of Sciences · 22 Sept 2026 · Journal Article
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NAD(+) depletion by catalytic TIR domains triggers a distinct form of regulated necrosis in mammalian cells.
Proceedings of the National Academy of Sciences · 22 Sept 2026 · Journal Article
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Dissipation of lysosome pH impairs formation and collapses existing LPS-induced lysosome tubules in macrophages
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.25.677195
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Populus euphratica PeIDD5 regulates PeNAC029 to suppress salt tolerance in poplars.
Plant Physiology and Biochemistry · 15 Sept 2026 · Journal Article
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Genetic risk implicating endolysosomal network genes correlates with endolysosomal dysfunction across neural cell types in Alzheimer's disease
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.16.643481
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Lysosomal signaling pathways influence heart rhythm, and regulate atrial function
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.10.597905
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PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.
Journal of Cell Biology · 7 Sept 2026 · Video-Audio Media
PIKfyve regulates ER morphology and dynamics by modulating lysosome-ER contacts, with its inhibition causing less reticulated ER and impaired motility.
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Whole-organism screening in a zebrafish model of CLN2 disease identifies pregnenolone as a modulator of lysosomal functions with anti-epileptic properties
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.26.670480
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Cas12a chRDNA-mediated in vivo genome editing for high specificity functional gene disruption.
Molecular therapy. Nucleic acids · 2 Sept 2026 · Journal Article
Cas12a chRDNA genome editing achieves near-complete target gene disruption with high specificity and no detectable off-target effects in vivo.
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A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis
bioRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.25.747102
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Lipids Regulate Export of Lysosomal Enzymes from the Endoplasmic Reticulum
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.16.719038
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CRISPR/Cas trans-cleavage activity in pathogen detection: research progress and innovations.
Biotechnology advances · 20 Aug 2026 · Review
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https://jclub.com.au/a/42624339
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PARP14-dependent ADP-ribosylation of cytoplasmic SQSTM1/p62 foci supports innate immune signaling
bioRxiv · 19 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.29.601315
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SARS-CoV-2 protein ORF3a induces Atg8ylation of lysosomal membranes
bioRxiv · 14 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.09.12.612614
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Amiloride mitigates respiratory distress caused by WFDC2 deficiency via inhibiting the epithelial sodium channel.
Nature Communications · 12 Aug 2026 · Journal Article
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https://jclub.com.au/a/42717213
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Yeast PI(3,4,5)P3 controls vacuole fusion through Vam7 and membrane microdomain assembly
bioRxiv · 11 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.01.668199
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Conformational changes underlying electromechanical transduction in prestin resemble a transport transition in pendrin
bioRxiv · 5 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.06.730624
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Accessing pore-blocker bound and alternative conductive conformations of TMEM16A using PIP2-assisted adaptive sampling
bioRxiv · 5 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.717600
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