PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

PIKfyve regulates ER morphology and dynamics by modulating lysosome-ER contacts, with its inhibition causing less reticulated ER and impaired motility.

• Why it matters: Understanding PIKfyve's role is crucial because its dysfunction is linked to diseases, and it influences organelle interactions that are vital for cellular homeostasis.
• What they did: The study used cellular models to inhibit PIKfyve and observed ER and lysosome behavior, revealing changes in ER structure, lysosome clustering, and altered tethering at contact sites.
• The result: Findings demonstrate that PIKfyve maintains ER and lysosome interactions through phosphoinositide balance, offering insights into disease mechanisms and potential therapeutic targets.