bioRxiv · 3 Sept 2026 · Preprint · Open access

Whole-organism screening in a zebrafish model of CLN2 disease identifies pregnenolone as a modulator of lysosomal functions with anti-epileptic properties

Kiani, Civiletto + 12 more

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Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain.
Cell Reports · 1 Oct 2026 · Journal Article
Lysosomal lipid and protein changes in the aging brain show increased myelin components and disrupted sphingolipid breakdown, especially in microglia, indicating dysfunction.
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https://jclub.com.au/a/42826099
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Lysosomal microautophagic pathway links proteostasis to protein aggregation disease
bioRxiv · 29 Sept 2026 · Preprint
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- 4 cites
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https://jclub.com.au/a/10.1101/2020.08.11.245688
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Understanding the CLN2 Disease Journey: A Survey of Caregiver Experiences, Treatment Burden, and Treatment Perspectives
medRxiv · 27 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.31.26354557
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