PDE5a inhibitors like sildenafil reduce cancer metastasis by disrupting NPC1-mediated cholesterol trafficking, causing lysosomal cholesterol accumulation and impairing cell migration.
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Phosphodiesterase function and regulation
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Using CD115 instead of CLEC12A improves the precision of defining human common monocyte progenitors, revealing their molecular complexity.
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Integrating targeted genetic approaches with genome-wide evidence enhances clinical pharmacogenetics in psychiatry, especially for pharmacokinetic and pharmacodynamic traits.
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Dendritic spine nanostructure analysis reveals that increased Ecrg4 expression links to schizophrenia-related spine abnormalities in mouse models.
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Azithromycin reduces the risk of moderate or severe COPD exacerbations by 17% compared to roflumilast in routine clinical practice among patients over 40.
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