PADI1 and PADI3 promote resistance to KRAS inhibitors by sustaining mitochondrial adaptation in KRAS-driven tumors.
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Protein Tyrosine Phosphatases
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In PTPN11-mutant juvenile myelomonocytic leukemia, dual NLRP3 and PTGS2 inhibition combined with MEK blockade significantly prolongs survival and reduces leukemic burden in models.
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Loss of FAP-1 causes defective megakaryocyte membrane development, impaired platelet function, and myelofibrosis-like features in mice, with 50% developing severe symptoms.
A de novo 15q11.1-q13.3 duplication with tetrasomy and trisomy was linked to severe neurodevelopmental delays and autism in a girl, expanding known genomic variations.
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NtA motif-driven asymmetric BRAF dimerization activates MEK1 phosphorylation, revealing a structural basis for BRAF's role in cancer signaling.
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