Research area · week to 3 Oct 2026

Glioma Diagnosis and Treatment

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DNA, Peptide Vaccines Advance Against GBM.
Cancer Discovery · 3 July 2026 · News
DNA-based GNOS-PV01 and peptide-based NeoVax show promise as personalized vaccines for glioblastoma, with GNOS-PV01 effective against the challenging MGMT-unmethylated subtype.
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Wild type bone marrow-derived microglia-like cells mitigate strain-dependent neuropathology in Csf1r mutant mice.
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.01.16.633478
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Single-Cell Analysis of Non-Functioning Gonadotroph Tumors Identifies Lineage Infidelity and Tumor Growth Programs
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.17.752250
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CNM-Au8 Treatment Is Associated With Reduced Chronic Lesion Tissue Expansion in Relapsing-Remitting Multiple Sclerosis
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363841
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Experimental Framework to Investigate Glioma in Organotypic Human Cortex
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753089
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Exploring the gut-brain axis in glioblastoma: a prospective case-control study of the gut bacteriome and mycobiome
medRxiv · 24 Sept 2026 · Preprint
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CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis
bioRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.03.08.584083
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CPT1A-mediated IDO1 succinylation shapes EGFRvIII-driven resistance to tumor electric field therapy in glioblastoma.
Nature Communications · 23 Sept 2026 · Journal Article
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https://jclub.com.au/a/42806046
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Temporal regulation of progenitor lineage progression and output by NFIs underlying human neocortical malformation.
Neuron · 18 Sept 2026 · Journal Article
NFIs act as conserved global temporal regulators of radial glial progenitor development, with mutations causing bidirectional impairments linked to human neocortical malformations.
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Autophagy inhibition sensitizes radiotherapy responses in high-grade mutant IDH1 glioma.
Nature Communications · 18 Sept 2026 · Journal Article
Inhibiting autophagy with ATG7 silencing nanoparticles enhances radiotherapy effectiveness in high-grade mutant IDH1 gliomas, leading to tumor regression and long-term survival.
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Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma.
Nature Medicine · 17 Sept 2026 · Journal Article
Levetiracetam extends survival in children with diffuse midline glioma by targeting GABAergic synapses, but not in other glioma subtypes.
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https://jclub.com.au/a/42754728
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Local Tumor Microenvironment Niches Correlate with Survival and Immunotherapy Response in Human Glioblastoma
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.23.707276
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A Drug-Specific, Half-Life-Adjusted Framework for Classifying CNS-Active Systemic Therapy Exposure During and After Radiotherapy
medRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.11.26354463
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Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG)
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.17.731637
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Spatial analysis reveals the evolving organization of IDH-mutant glioma.
Cancer Cell · 14 Sept 2026 · Journal Article
Spatial organization of IDH-mutant gliomas shifts from anatomy-driven in low-grade tumors to hypoxia-driven in high-grade tumors, revealing two distinct axes of tumor structure.
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Mapping multiregional imaging-localized biopsies to MRI habitats reveals biologically significant glioma tissue states and associated patterns of cohabitating cellular subpopulations
bioRxiv · 12 Sept 2026 · Preprint
Mapping 202 MRI-localized biopsies from 58 glioma patients reveals three key tissue states and 14 MRI habitats linked to tumor biology and progression.
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https://jclub.com.au/a/10.1101/2022.03.23.485500
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Sensitive Glioma Detection and Recurrence Monitoring Using a Machine Learning Model Based on Circulating Monocytes
medRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.26354409
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Computational prioritization of candidate TCDD-associated targets in retinoblastoma using network toxicology and transcriptomic analysis.
Frontiers in Genetics · 9 Sept 2026 · Journal Article
Eighteen candidate TCDD-associated targets, including five hub genes, were identified in retinoblastoma, with CDK1 showing the strongest link to cell-cycle dysregulation.
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https://jclub.com.au/a/42775123
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Consistent DNA methylation patterns enable accurate and interpretable cross-platform classification of central nervous system tumors
medRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.07.25337348
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Testable Clinical Signatures for Go-or-Grow Dichotomy of Gliomas along Anisotropic White-matter Tracts
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.01.735477
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Deacetylase-independent HDAC1 condensation defines temozolomide response in glioblastoma.
Nature Chemical Biology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/41513853
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A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.19.705289
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Ang2 and TAT targeting of leptomeningeal disease by the intravenous and intrathecal routes: a comparative analysis
bioRxiv · 29 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.29.735336
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Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2022.09.03.506476
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Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissue
bioRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.02.28.640804
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Longitudinal tractography monitors cortical stroke-induced thalamocortical degeneration and neuroprotection by human iPSC-derived neurons
bioRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.17.643730
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The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.
Cell · 20 Aug 2026 · Clinical Trial, Phase I
Endogenous immune responses, especially natural killer cell expansion, are crucial for successful CAR T cell therapy in recurrent GBM, with responders showing significant immune remodeling.
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https://jclub.com.au/a/42296961
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Dynamic Quantum Clustering of Glioma RNA-seq Reveals Interpretable Tumor States Linked to Diagnosis and Survival
medRxiv · 19 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.26350535
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Integrating single-cell transcriptomics with deep learning for glioblastoma treatment.
Frontiers in Genetics · 17 Aug 2026 · Review
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https://jclub.com.au/a/42676589
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Targeting SAGA/ATAC complexes disrupts chromatin regulation and cholesterol metabolism in diffuse midline glioma
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.22.701194
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Integrative multi-omics framework identifies phenotypically impactful driver pathways in glioblastoma multiforme
bioRxiv · 15 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.02.28.640792
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