AI-monitored bioadhesive for sutureless microvascular anastomosis.

iMAS, an integrated microneedle-interlocking adhesive system for rat microvascular anastomosis, reduced procedural time by 78% and suppressed neointimal hyperplasia.

• Why it matters: Microvascular suturing is difficult and slow, and failures like thrombosis are linked to the wet, dynamic surgical environment where current adhesives underperform.
• What they did: The study built iMAS with a hydrophobic polymer matrix and tetrahedral microneedles, plus an AI-assisted wireless sensor for continuous real-time monitoring of hemodynamics and graft health.
• The result: In rat models, iMAS both shortened anastomosis time by 78% and suppressed neointimal hyperplasia, while the sensor enabled predictive identification of complications such as stenosis and transplant rejection.

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