Gene Expression Nebulas 2.0: an updated resource of gene expression profiles by incorporating more datasets, annotations, and functionalities.

GEN 2.0 expands Gene Expression Nebulas across 100 species, increasing datasets to 668 and samples to 102,679, while adding spatial transcriptomics and disease annotations.

• Why it matters: Prior standardized transcriptomic resources lacked sufficient coverage, richer annotations, and AI-ready profiles, limiting cross-species and disease-focused analyses.
• What they did: The team updated GEN by incorporating more datasets and metadata, adding spatial transcriptomics plus disease-associated expression annotations from 82 human bulk RNA-seq datasets across 62 disease categories and 12 disease systems.
• The result: GEN 2.0 now supports AI-oriented gene expression profiles, a web submission service, and an updated cross-species/tissue/disease comparison tool, enabling broader mechanistic and regulatory studies.

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