Nucleic Acids ResJClub
The Immune Epitope Database (IEDB) in 2026: updates of immune receptor data.
Nucleic Acids Research · · Journal Article
Scheffer, Richardson + more
Abstract ↗AI summary
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The Immune Epitope Database (IEDB) has standardized and validated ∼235 000 T cell receptors and ∼6400 B cell receptors/antibodies with experimentally verified epitope specificity.
- Why it matters: Receptor curation across 3879 references creates inconsistencies in gene naming and CDR boundaries that complicate computational queries and analyses.
- What they did: The team rebuilt the pipeline to generate IUIS/IMGT-compliant V/D/J gene names and consistently delimit V, CDR1, CDR2, CDR3, and Junction sequences, re-curating anomalous receptors from 822 references.
- The result: The updated IEDB interface adds receptor search on the homepage, species and V/J gene filters, and AIRR-format exports, enabling easier bioinformatics and cross-repository integration.
The findingWhy it mattersWhat they didThe result
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