Tumor Cells Hijack Coagulation Signaling to Enable Immune Escape and Metastatic Dissemination.

Tissue factor (F3) is upregulated in gastric cancer lymph node metastasis and is linked to impaired immune checkpoint blockade responsiveness and poor outcome.

• Why it matters: Lymph node metastasis is a key step in cancer progression and strongly affects how well immune checkpoint blockade works, but the molecular bridge to immune suppression is unclear.
• What they did: The study mapped an F3 pathway in gastric cancer, showing F3 intracellular domain binding eEF1A1 to enhance STAT3 phosphorylation and drive CCL20 expression that recruits CCR6+ regulatory T cells; olsalazine disodium disrupted this axis.
• The result: Blocking the F3-eEF1A1-STAT3-CCL20 signaling with olsalazine disodium suppressed tumor growth, reduced Treg infiltration, and restored ICB sensitivity without perturbing basal coagulation.

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