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Self-amplifying RNA vaccines encoding chimeric and mosaic hemagglutinins confer immunity against phylogenetically diverse influenza A viruses.
Cell Reports · · Journal Article
Abbad, Yellin + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Group 1 chimeric HA self-amplifying mRNA vaccines (cH8/1-cH5/1) elicit broad cross-reactive antibodies and confer complete protection against diverse H1N1 strains spanning decades of antigenic drift.
- Why it matters: Annual influenza vaccine reformulation due to antigenic drift leaves gaps in protection, motivating broadly protective designs that cover phylogenetically diverse influenza A viruses.
- What they did: After prime-boost immunization, group 1 cHA and group 2 cHA/mHA samRNA encoding HA phylogenetic groups 1 and 2 were tested for antibody breadth, Fc-mediated effector functions, CD4+ T cell responses, and challenge outcomes, including heterosubtypic H7N9.
- The result: Group 2 cHA and mHA provide comparable breadth against multiple H3N2 strains and heterosubtypic H7N9 challenge, with cHA showing superior cross-group protection; passive serum transfer and low-dose efficacy (0.4 μg) support antibody-mediated, dose-sparing protection.
The findingWhy it mattersWhat they didThe result
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