Shape-memory scaffold targets inflammation and fibrosis to restore endometrium and fertility in intrauterine adhesions.

A bi-drug, bifunctional biodegradable shape-memory regenerative scaffold (BiSMR) restores endometrium and fertility in rat intrauterine adhesions, improving implantation and live birth rates while reducing fibrosis.

• Why it matters: Intrauterine adhesions are a major infertility cause, and existing therapies inadequately prevent fibrosis and fail to restore functional endometrium.
• What they did: Proteomic profiling across chemical, mechanical, and combined injury models identified inflammatory activation and impaired regenerative programs, motivating EGCG plus 17β-estradiol (E 2 ) delivery via a PLTG backbone and PDA-EGCG@HAMA coating with sequential release.
• The result: In rat IUA models, BiSMR restored endometrial structure and vascularization, reduced fibrosis, improved implantation and live birth rates, and proteomics showed down-regulation of fibrosis- and inflammation-related effectors with recovery of regenerative pathways.

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