Combating drug-resistant Aeromonas veronii: Multiomics revealed the antibacterial mechanism of resveratrol.

Resveratrol inhibits Aeromonas veronii with a minimum inhibitory concentration of 128 μg/ml and minimum bactericidal concentration of 256 μg/ml, disrupting cell wall/membrane integrity.

• Why it matters: Rising antibiotic resistance in Aeromonas veronii strains creates a need for natural antimicrobials and for mechanistic evidence to support their use.
• What they did: The work combined transcriptomic and metabolomic analyses with assays showing reactive oxygen species accumulation and reduced adenosine 5'-triphosphate synthesis after resveratrol exposure.
• The result: In a hybrid sturgeon infection model, resveratrol-nanoemulsion improved survival, lowered tissue bacterial loads, reduced oxidative stress and inflammation, and restored intestinal barrier function.

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